Famous Persons from Empalme, Sonora, Mexico
- Santiago Merlo - Born on August 30, 1998 - Association football player
- Matías Viña - Born on November 9, 1997 - Association football player
- Jesús Francisco López - Born on March 18, 1997 - Association football player
- Emiliano Fernández - Born on December 12, 1992 - Association football player
- Martin Ángel Martínez - Born on February 12, 1991 - Boxer
- Marcelo Fernández - Born on April 4, 1988 - Association football player
- Gabriel Alejandro Martínez - Born on April 23, 1987 - Boxer
- Jorge Heredia - Born on September 27, 1985 - Journalist, and Television presenter
- Ricardo Castillo - Born on June 7, 1979 - Boxer
- José Luis Castillo - Born on December 14, 1973 - Boxer
- Elizabeth Carvajal-Millan - Born on October 20, 1972 - Food scientist, and Scientist
- Abel Balbo - Born on June 1, 1966 - Association football player, Association football coach, and Singer
- Ángel Pini Elías - Born on May 18, 1957 - Politician
- Jesús Zambrano Grijalva - Born on October 1, 1953 - Mathematician, and Politician
- Rodolfo "Rduy" Hernández Acosta - Born on October 19, 1951 - Baseball player
- Rudy Hernández - Born on October 18, 1951 - Baseball player
- Ronnie Camacho - Born on October 26, 1935 - Baseball player (died: October 26, 1935)
- Miguel Gaspar - Born on September 19, 1929 - Baseball player - Mexican Professional Baseball Hall of Fame (died: July 22, 2012)
- Francisco Alcaraz - Born on October 26, 1920 - Baseball player - Mexican Professional Baseball Hall of Fame (died: May 1, 1996)